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WHY ARE PROBIOTIC MICROBES THE FUTURE OF SKINCARE?

IN THE FUTURE WE’LL ALL LOOK AFTER THE MICROBES ON OUR SKIN.

We’ll understand that they are our symbiotic allies and that they protect our skin from pathogens and toxins. We’ll stop using anti-bacterial products that kill both  good and bad microbes. We will choose products without synthetic ingredients and  harsh preservatives that pollute and destabilise our skin microbiome. We’ll feed our microbes and use treatments that seed our skin with beneficial probiotic species to help ease sensitivity and slow the rate of ageing.

THE FUTURE IS PRO-BIOTIC NOT

ANTI-BIOTIC…

 AND THAT FUTURE STARTS NOW.

IT’S TIME TO REWILD

Skin deseases like eczema and acne are almost non-existent in hunter-gatherer communities but they have  now become very common across the world. Maybe it’s time to end the war on germs and rewild our skin?

IN THE FUTURE WE’LL ALL LOOK AFTER THE MICROBES ON OUR SKIN.

We’ll understand that they are our symbiotic allies and that they protect our skin from pathogens and toxins. We’ll stop using anti-bacterial products that kill both  good and bad microbes. We will choose products without synthetic ingredients and harsh preservatives that pollute and destabilise our skin microbiome. We’ll feed our microbes and use treatments that seed our skin with beneficial probiotic species to help ease sensitivity and slow the rate of ageing.

THE FUTURE IS PROBIOTIC NOT ANTI-BIOTIC… AND THAT FUTURE STARTS NOW.

IT’S TIME TO REWILD

Skin deseases like eczema and acne are almost non-existent in hunter-gatherer communities but they have  now become very common across the  world. Maybe it’s time to end the war  on germs and rewild our skin?

SEED AND FEED

Probiotics are live microbes that are good for you.
Probiotics can shift the skin’s ecology to favour a diverse and harmonious ecosystem that is healthy enough to resist attacks from pathogens and to reduce the impacts of ageing on the skin. Esse seeds the skin with beneficial microbes that compete with pro-ageing species
and feeds with prebiotic nutrients to select for microbes that improve the microbial ecology on the skin.
We use mild preservatives, gentle surfactants, and we keep the pH of our products between 4 and 5. We also pay particular attention to preventing the pollution of the
skin’s ecosystem and our products are certified organic by Ecocert.

SEED AND FEED

Probiotics are live microbes that are good for you.

Probiotics can shift the skin’s ecology to favour a diverse and harmonious ecosystem that is healthy enough to resist attacks from pathogens and to reduce the impacts of ageing on the skin.

Esse seeds the skin with beneficial microbes that compete with pro-ageing species and feeds with prebiotic nutrients to select for microbes that improve the microbial ecology on the skin. We use mild preservatives, gentle surfactants, and we keep the pH of our products between 4 and 5. We also pay particular attention to preventing the pollution of the skin’s ecosystem and our products are certified organic by Ecocert.

I AM PROBIOTIC

“MICROBES CONTRIBUTE MORE GENES RESPONSIBLE FOR HUMAN SURVIVAL THAN HUMANS DO”   – Human Microbiome Project

I AM PROBIOTIC

“MICROBES CONTRIBUTE MORE GENES RESPONSIBLE FOR HUMAN SURVIVAL
                         THAN HUMANS DO”   Human Microbiome Project

A RADICAL SHIFT IN THINKING

Since the completion of the Human Microbiome Project, it has become clear that each of us is a complex mix of microbes and human cells.

There are more microbes in your body than human cells… at least ten times more if you include viruses … and this has fundamentally changed our understanding of what it means to be human.

You aren’t just you … you’re an ecology of thousands of interdependent species and you wouldn’t last long without your microbial friends.

MICROBE

a single-celled organism
(we choose to include viruses)

MICROBIOME

the sum total of all the
microbes living in and on you.

PROBIOTIC

live, beneficial microbe

A RADICAL SHIFT IN THINKING

Since the completion of the Human Microbiome Project, it has become clear that each of us is a complex mix of microbes and human cells.

There are more microbes in your body than human cells … at least
ten times more if you include viruses … and this has fundamentally
changed our understanding of what it means to be human.

You aren’t just you … you’re an ecology of thousands of interdependent species and you wouldn’t last long without your microbial friends.

MICROBE

a single-celled organism
(we choose to include viruses)

MICROBIOME

the sum total of all the
microbes living in and on you.

PROBIOTIC

live, beneficial microbe

There are 360 times more bacterial genes than human genes in your body

THERE ARE 360 TIMES MORE BACTERIAL GENES THAN HUMAN GENES IN YOUR BODY

YOUR MICROBES AREN’T JUST IN YOUR GUT

Most people associate probiotics with maintaining a healthy gut. The pie chart shows that your skin holds a large part of your microbial diversity. We have now discovered that optimal skin condition depends heavily on symbiotic relationships with the microbes living on and in it.

In the coming years, probiotics will become as important in skincare as they are in gut health.

WHY ARE WE ONLY HEARING ABOUT THIS NOW?

How did science miss something this big?

Microbes are about ten times smaller than human epithelial cells and they’re everywhere, so, unless you know what you’re looking for it’s difficult to see the big picture through a microscope.

It was only when scientists could see through the lens of next generation DNA sequencing that it became possible to take a proper roll-call of who was there.

The share of microbial diversity in different body niches

DNA sequencing has only recently enabled us to “see” and count our microbes

Just how small are microbes?

Each one of us is a complex
ecosystem, a harmonious mix of
human cells and microbes

Each one of us is a complex ecosystem, a harmonious mix of human cells and microbes

Each one of us is a complex ecosystem, a harmonious mix of human cells and microbes

What do my microbes do for me?

You have distinct microbiomes in your gut, your skin, your oral cavity, your airways and (if you’re female) your vagina. In all these sites, your microbes protect you from invading pathogenic microbes by competitive exclusion. This means that they occupy all the space and consume all the available food so that invaders can’t colonize.

In your gut, your resident microbes metabolize drugs, digest lactose, make essential amino acids, break down fibre, and make vitamins. Your gut microbiome largely determines whether or not you are overweight and influences your mood by producing a kind of endogenous valium.

Your microbiome also modulates your immune system and metabolizes toxins so that they can be excreted.

What do my microbes do for my skin?

In your skin, your microbes produce Hyaluronic Acid and other moisturising factors, modulate barrier function and immune response, maintain the skin’s pH, and help to shape the skin ecology by producing anti-microbial peptides.

You wear your microbes like living armour that protects you from invading pathogens.

Calm, healthy skin not only looks better but also ages slower than skin that is constantly in a state of low-level inflammation.

Probiotics can help to shift the microbiome to a healthy, balanced state. 

WHAT DO MY MICROBES DO FOR ME?

You have distinct microbiomes in your gut, your skin, your oral cavity, your airways and (if you’re female) your vagina. In all these sites, your microbes protect you from invading pathogenic microbes by competitive exclusion. This means that they occupy all the space and consume all the available food so that invaders can’t colonize.

In your gut, your resident microbes metabolize drugs, digest lactose, make essential amino acids, break down fibre, and make vitamins. Your gut microbiome largely determines whether or not you are overweight and influences your mood by producing a kind of endogenous valium.

Your microbiome also modulates your immune system and metabolizes toxins so that they can be excreted.

WHAT DO MY MICROBES DO FOR MY SKIN?

In your skin, your microbes produce Hyaluronic Acid and other moisturising factors, modulate barrier function and immune response, maintain the skin’s pH, and help to shape the skin ecology by producing anti-microbial peptides.

You wear your microbes like living armour that protects you from invading pathogens.

Calm, healthy skin not only looks better but also ages slower than skin that is constantly in a state of low-level inflammation.

Probiotics can help to shift the microbiome to a healthy, balanced state. 

THE SKIN MICROBIOME

RUNS DEEP

Before this experiment, it was assumed that the skin microbiome was on the surface
of the skin and that the tissues below the surface consisted only of human cells.

Richard Gallo and his team extracted DNA from 30μm horizontal sections of 6 mm punch biopsies of human facial skin and showed that there are strong populations of microbes throughout the epidermis, below the Basal membrane and all the way into the Adipose layer below the dermis.

Reference: Nakatsuji T, Chiang H-I, Jiang SB, Nagarajan H, Zengler K, Gallo RL. The microbiome extends to subepidermal compartments of normal skin. Nature communications. 2013;4:1431

You have lost some partners

You have lost some partners

Some of the factors that may have caused the loss of key microbial partners in the skin microbiome

Some of the factors that may have caused the loss of key microbial partners in the skin microbiome

The skin microbiome varies between body sites

From a microbe’s perspective  the skin can be broadly broken into three habitats … dry, moist  and oily. A bit like a coral reef, a  rainforest and a savannah.

Different species of microbe  flourish in different conditions.  The microbes that dominate  your dry forearm are different  from the ones that occupy your  much oilier forehead or nose.

The skin microbiome varies between body sites

From a microbe’s perspective  the skin can be broadly broken into three habitats … dry, moist  and oily. A bit like a coral reef, a  rainforest and a savannah.

Different species of microbe  flourish in different conditions.  The microbes that dominate  your dry forearm are different  from the ones that occupy your  much oilier forehead or nose.

WHAT PROBIOTICS DO FOR YOUR SKIN

> PROTECT YOU FROM PATHOGENS (LIKE ARMOUR FOR YOUR FACE)

Probiotics protect your skin from pathogens. They can form a layer and use all the available nutrients so that opportunistic pathogens can’t colonise. They also produce anti-microbial peptides that make life really tough for incoming bad guys.

> MANUFACTURE MOISTURISING FACTORS LIKE HYALURONIC ACID

Probiotic bacteria produce hyaluronic acid which is an intensely moisturising active that naturally holds moisture in your skin.They have also been shown to decrease Trans Epidermal Water Loss and improve skin hydration by improving barrier functioning skin.

> MAINTAIN SKIN pH (VERY IMPORTANT, DON’T MESS WITH pH)

Many probiotics produce Lactic acid and other acids that keep your skin’s pH in the optimal range – 4,5 to 5. As we age, our skin pH drifts higher and higher. A little help to keep the pH down will be welcomed by your skin.

> MAINTAIN CALM AND REDUCE SENSITIVITY

Probiotic bacteria on the skin can communicate with your skin’s immune system to keep it in check so that it doesn’t overreact. The improvement of barrier function also prevents many toxins from penetrating the skin in the first place.

> SLOW AGEING (HEALTHY SKIN AGES SLOWER)

We can’t stop the clock… but we can’t deny that if we treat skin badly, it will age  faster. Probiotics help slow the signs of ageing by protecting your skin and by keeping your own immune response at bay. They have also been shown to reduce wrinkles and improve skin firmness and elasticity. Healthy skin ages slower.

> PROTECT YOU FROM PATHOGENS (LIKE ARMOUR FOR YOUR FACE)

Probiotics protect your skin from pathogens. They can form a layer and use all the available nutrients so that opportunistic pathogens can’t colonise. They also produce anti-microbial peptides that make life really tough for incoming bad guys.

> MANUFACTURE MOISTURISING FACTORS LIKE HYALURONIC ACID

Probiotic bacteria produce hyaluronic acid which is an intensely moisturising active that naturally holds moisture in your skin.They have also been shown to decrease Trans Epidermal Water Loss and improve skin hydration by improving barrier functioning skin.

> MAINTAIN SKIN pH (VERY IMPORTANT, DON’T MESS WITH pH)

Many probiotics produce Lactic acid and other acids that keep your skin’s pH in the optimal range – 4,5 to 5. As we age, our skin pH drifts higher and higher. A little help to keep the pH down will be welcomed by your skin.

> MAINTAIN CALM AND REDUCE SENSITIVITY

Probiotic bacteria on the skin can communicate with your skin’s immune system to keep it in check so that it doesn’t overreact. The improvement of barrier function also prevents many toxins from penetrating the skin in the first place.

> SLOW AGEING (HEALTHY SKIN AGES SLOWER)

We can’t stop the clock… but we can’t deny that if we treat skin badly, it will age  faster. Probiotics help slow the signs of ageing by protecting your skin and by keeping your own immune response at bay. They have also been shown to reduce wrinkles and improve skin firmness and elasticity. Healthy skin ages slower.

Probiotics protect by competitive exclusion

Beneficial microbes use all available nutrients and occupy all the space to exclude opportunistic and pathogenic microbes.

Probiotics protect

Probiotics communicate with human cells to increase their production of Anti-Microbial Peptides (AMPs).
Anti-Microbial Peptides selectively kill pathogenic microbes but don’t harm beneficial microbes.

Probiotics moisturise

Probiotic microbes produce moisturising factors like hyaluronic acid.

Probiotics enhance barrier function

Probiotic microbes communicate with cells in the stratum granulosum to increase the number and quality of Tight Junctions. Tight Junctions keep water in the skin and keep toxins and invading cells out.

The 4 levels of probiotics in skincare

1 – BROTH

Microbes are removed and the ferment is used. Probiotic microbes are inoculated into a liquid nutrient broth; allowed to multiply and then the broth is filtered off and used in the final products.

2 – LYSATE

Microbes are broken and their contents are used

3 – TYNDALLISATION

Microbes are killed by heat, but are kept whole. Instead of losing the probiotic cells, they are deactivated using heat and then added to the product.

Microbes are live and able to colonise. A true probiotic product is alive and can grow to form colonies. The product will have millions of colony forming units per millilitre (CFU per ml)

4 – LIVE PROBIOTIC

In the future we’ll all look after the microbes on our skin.

We’ll understand that they are our symbiotic allies and that they protect our skin from pathogens and toxins. We’ll stop using anti-bacterial products that kill both good and bad microbes. We will choose products without synthetic ingredients and harsh preservatives that pollute and destabilise our skin microbiome. We’ll feed our microbes and use treatments that seed our skin with beneficial probiotic species to help ease sensitivity and slow the rate of ageing.

 

The future is pro-biotic not anti-biotic… and that future starts now.